Journal of Qassim University for Science

Synthesis of Novel Thiosemicarbazones and Their Molecular Docking Simulations as Inhibitors of α-Amylase and α-Glycosidase Enzymes

Siwar Ghannay — 2024-12-31

In this study, a new chiral aldehyde featuring an isoxazolidine scaffold was synthesized. This compound served as a precursor for the preparation of three novel isoxazolidine-thiosemicarbazone hybrids. In a molecular docking study (MDS), compound 7a emerged as the top performer, showing the highest binding affinity with binding energies of -8.5 kcal/mol for alpha-amylase and -7.5 kcal/mol for alpha-glucosidase.

Application of Drug–Metal Ion Interaction Principle in Potentiometric and Conductometric Determination of Folic Acid

Osman Farghaly — 2024-12-31

This study includes carefully selecting nine metal ions; magnesium, calcium, cobalt, nickel, copper, lead, chromium, iron and thorium to clarify their interaction with folic acid (FA) by potentiometric technique. The association constant of folic acid and the strength constants of the complexes made at ionic strength, I = 0.1molar NaClO₄ in aquatic medium at room temperature were calculated. Complexes were obtained with metal - FA ratios of 1:1, 1:2 and/or 1:3 according to the nature of the metallic ions and folic acid. Also, the instruction of strength constants of the double complexed was tested. The connection of the complexes was determined through conductivity measurement method. The ionic balances of the FA and its complexes with diverse metallic elements in medium were examined. Simple, accurate, quick and little -cost potentiometric and conductivity procedures are used to determine folic acid (FA) in pure pharmaceutical samples. The potentiometric technique is built on the direct titration of folic acid in aqueous medium 0.1 M NaOH at µ=0.5NaClO₄ and 25±1.0^oС in the presence of a composite glass electrode and using the standard addition method, the detection and quantitation restrictions were establishing to be 0.005 milligram/ml, with a standard deviation, SD=0.002, and a correlation coefficient, R=0.9943 (n=5), and the linear concentration ranges were 0.005 to 0.07 mg/ml. This method was likewise used for the estimation of FA in pure solutions and tablets and satisfactory results were obtained. No interventions were detected in the occurrence of public constituents of the samples under study. The recovery of folic acid from different dosage tablets ranged from 97.3 to 98.6%.

The Linear Operators for Partial Ordered Banach Spaces

Manal Juma — 2024-12-31

In this study, we endeavour to prove that K(X, Y)is a structure and both sufficient to R.D.P .I will check
that L(X, Y) is conditionally complete or can contain a positive cone. I'm trying to find the conditions that
make K(X, Y) a network that has an approximate standard of unity.

Event-triggered Impulsive Control for Fractional-Order Chaotic Financial System

Mohsen Dlala — 2024-12-31

The exponential stabilization of fractional-order differential systems is examined through the utilization of event-triggered impulsive control (ETC). The impulsive control strategy is characterized by a triggering mechanism, which relies on the states of the systems. Updates to the controller exclusively occur at impulsive moments. Decreasing the frequency of controller updates leads to a reduction in the utilization of communication bandwidth and computational resources. Moreover, the effectiveness of the theoretical findings is demonstrated through a numerical illustration involving simulation on a chaotic fractional-order system within the domain of finance.

Microwave Assisted Multicomponent Design of Methyl 2-(3-alkyl-4-oxo-2-(pyridin-3-ylimino)thiazolidin-5-ylidene)acetate as Antimicrobial Agents

Saleh Al-Ghamdi — 2024-12-31

An effective and simple designing of methyl 2-(3-alkyl-4-oxo-2-(pyridin-3-ylimino)thiazolidin-5-ylidene)acetate via three-components reaction of 3-pyridyl isothiocyanate, primary aliphatic amines & dimethyl acetylenedicarboxylate under both microwave reaction conditions was introduced. Furthermore, the novel 1,3-thiazolidin-4-on derivatives were screened against six microorganisms. The pathogenic microorganisms that were selected included Aspergillus flavus and Chrysosporium keratinophilum as fungus, Pseudomonas aeruginosa and Escherichia coli as Gram-negative bacteria, & Staphylococcus aureus and Bacillus cereus as Gram-positive bacteria. Compounds 7 and 8 is the greatest promising antibacterial & antifungal agent may be due to the increase in the aliphatic chain and the presence of the hydroxyl group.

Calculating Gamow-Teller and Fermi Strength Function Using Two-Particle Two-Hole

Afnan Al-Shammari — 2024-12-31

In this study, we investigated the transitions of all types of beta decays using the two-particle and two-hole techniques. Specifically, we calculated the binding energy for Fermi decay and Gamow-Teller transitions by applying this technique to several intermediate isotopes. This involved calculating the transition forces and matrix elements for both Gamow-Teller and Fermi. These calculations were crucial for determining the half-life values of these isotopes and comparing them with existing experimental values. Our results demonstrate a significant agreement between the theoretical and experimental outcomes. Hence, we obtain the reduced amplitudes and the log ft factor and the half-lives of the decay. Beta b ^- and beta b ⁺/EC transitions from light to medium nuclei. The nuclei are ⁶He, ¹⁸Ne, ¹⁸F, and ⁴²Sc.

Numerical Study of Metal Hydride Beds with LaNi4.88Al0.12 Alloy for Hydrogen Compression

Alduayghiri Ruqayyah Ali M — 2024-12-31

The adsorption of hydrogen energy as a renewable energy carrier is particularly attractive because of the enormous demand for energy and the accelerated depletion of fossil fuel resources, so the development of an efficient technique for its storage is essentially essential. In the future, hydrogen energy appears to be an attractive substitute for fossil fuels like coal and oil. Because of its energy value, hydrogen energy is advantageous because it is renewable and its use would reduce the emission of pollutants into the environment. However, the problem of storing and transporting hydrogen efficiently and safely prevents its wide use and commercialization.

The LaNi4.88Al0.12 data show that heat transfer to and from the hydride bed significantly affects the hydrogen reaction duration in metal-hydride reactors (MHRs). In this work, the operational parameters of the heat exchanger were evaluated numerically to ascertain their impact on the MHR charging process's performance. The reactor's charge time is greatly shortened when the effects of various parameters (cooling fluid (T_F) temperature, applied hydrogen (P_H2) pressure in absorption and desorption cases) are examined and the results indicate that careful selection of these parameters is critical.