The protective effect of Moringa olifera against complications of type2 diabetes mellitus in male albino rats.

Abstract

Background: Diabetes mellitus, particularly type 2 (T2DM), is one of the most common diseases. T2DM has been associated with stress and a change in lifestyle. Regulation of postprandial blood glucose levels and the use of some natural plant extracts with inhibitory actions against carbohydrate digestion enzymes like alpha-amylase and fewer adverse effects than synthetic medicines are potential methods for preventing dietary carbohydrate absorption. This study shows the anti-diabetic effects of Moringa olifera extract on insulin and blood glucose in diabetic rats given streptozotocin (STZ) treatment.

Methods: The experiment was performed on 40 Wistar male rats; the experimental study included 4 groups: (I) normal rats and (II)normal rats orally received an aqueous extract of Moringa (500 mg/kg/day) for consecutive 4 weeks (III)diabetic group; male albino rats injected with a single intraperitoneal dose of Streptozotocin 55 mg/kg b.w.t. (IV) Streptozotocin-treated rats received an aqueous extract of Moringa 500 mg/kg/day orally for consecutive 4weeks.

Results: The results of the following study showed that the injection of STZ resulted in a decline in insulin and an increase in glucose.

It was also revealed that Moringa olifera extract has more anti-diabetic effect against streptozotocin treatment due to its higher phenolic content and its effect on decreasing the activity of α-amylase. This suggests that MAE leaf decreased postprandial glucose levels by slowing amylase-mediated glucose uptake.