The ameliorating effect of camel milk against liver toxicity induced by levofloxacin in male albino rats

Abstract

. Abstract:

-Background: Levofloxacin (Levo) is an antibiotic originating from the second generation of fluoroquinolones. It is used to treat infections of the respiratory tract, urinary tract, and genital tract. In spite of its great potency in the treatment of many diseases it has many side effects such as hepatotoxicity & renal toxicity.

- Objectives: The current study aimed to examine the therapeutic potential of camel milk to attenuate the liver toxicity of levofloxacin on some biochemical parameters in male albino rats.

- Methodology: The study investigated the effect of a dose (100 mg/kg) of levofloxacin for 10 days and evaluation of treatment with camel milk (5 ml/rat/day) for 15 days, on biochemical parameters: Glutamate-oxaloacetate (GOT), Glutamate pyruvate transaminase (GPT), total bilirubin (T.BIL), direct bilirubin(D.BIL), indirect bilirubin(Ind.BIL), Glucose, values were assessed.40 albino male rats weighing between (150 -180 g) were divided into four groups, including ten in each group, as follows: G1: regular rodent food and water are given to the control group. G2: CM (5ml/rat/day) for 15 days in drinking bottles. G3: oral administration of LFX through gastric tube (100mg/kg body wt.) for 10 days. G4: oral administration of LFX (100mg/kg body wt.) for 10 days, followed by CM (5ml/rat/day) for 15 days in drinking bottles.

- Results: The activities of transaminases (GOT), (GPT), levels of:(T.BIL), (D.BIL), and (Ind.BIL), in G3:(LFX-group) significantly increased(p≤0.01) by (42.4%,64.5%,151.4%,154.4%,148.8%) respectively after treatment with the antibiotic levofloxacin (LFX) at a dosage of (100 mg/kg/B wt) for 10 days. Additionally, there was a notable drop in serum glucose level (p≤0.01) by (-28.9%) in comparison to the control group of the above. While treatment with camel milk (5 ml / rat / day) for 15 days in G2: (CM-group) did not result in any significant difference (p< 0.01) in the above parameters compared to the control group. Oral administration of G4:(CM+LFX/group) for 15 consecutive days showed a less significant decrease (p≤0.01) in the activities of (GOT), (GPT) (-7.6%, -13.6%) respectively. While the results of (T.BIL), (D.BIL) and (Ind.BIL) showed a significant improvement by ( -33.3%, -28%, -35.6%) respectively. And a significant increase (p≤0.01) by (17.6%) in the values of glucose compared to the group treated with levofloxacin.

- Conclusion: The study's findings support the use of camel milk as an external antioxidant supplement to lessen the toxicity of levofloxacin.