Metal complexes developing for ramipril determination in tablet by potentiometric technique

Abstract

Three metallic ions viz; Cr⁺³, Fe ⁺³and Al⁺³ was nominated to clarify the relations of these metallic elements with ramipril (RAM) by means of potentiometric technique. The protonation constant of  RAM and formation constants of complexes constructed at ionic strength (I = 0.1 M sodium nitrate) have been tabularized in aquatic medium at room temperature. The ratios of complexes 1:1, 1:2 and/or 1:3 metallic ions towards RAM relations are developed dependent on the nature of RAM or metallic ions. The order of formation constants of the two complexes was studied. The potentiometric method was employed to approve the ratios of M-RAM binary complexes formed. This method was used successfully to detect RAM in tablets. The standard addition process built on Gran plan, RAM was acceptably estimated at ionic strength I= 0.4 M NaNO₃, through a concentration variety of 0.753–12.05 mg/mL (standard deviation SD = 0.11, correlation coefficient R = 0.9992 (n = 5)) by a lower detection limit (LOD) equals 0.55 milligram/milliliters (standard deviation SD = 0.15, R = 0.9992 (n = 5)). In the presence of famous tablet excipients, no interfering was detected. The ratio of RAM gets back from tablet dosage forms diverse after 99.5 to 100.6 % with SD ranging from (0.39 – 0.7).