Microwave Assisted Multicomponent Design of Methyl 2-(3-alkyl-4-oxo-2-(pyridin-3-ylimino)thiazolidin-5-ylidene)acetate as Antimicrobial Agents

Abstract

An effective and simple designing of methyl 2-(3-alkyl-4-oxo-2-(pyridin-3-ylimino)thiazolidin-5-ylidene)acetate via three-components reaction of 3-pyridyl isothiocyanate, primary aliphatic amines & dimethyl acetylenedicarboxylate under both microwave reaction conditions was introduced. Furthermore, the novel 1,3-thiazolidin-4-on derivatives were screened against six microorganisms. The pathogenic microorganisms that were selected included Aspergillus flavus and Chrysosporium keratinophilum as fungus, Pseudomonas aeruginosa and Escherichia coli as Gram-negative bacteria, & Staphylococcus aureus and Bacillus cereus as Gram-positive bacteria. Compounds 7 and 8 is the greatest promising antibacterial & antifungal agent may be due to the increase in the aliphatic chain and the presence of the hydroxyl group.