1,2,4-Triazole as promising scaffold: Synthetic and Biological Aspects

Abstract

1,2,4-triazoles are valuable scaffolds in medicinal chemistry due to their diverse biological activities. This review delves into synthesis strategies, such as iodine-mediated, microwave-assisted, solid-phase, and liquid-phase approaches, and their biological relevance. These methods yield efficient access to 1,2,4-triazoles, which demonstrate significant anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiviral properties. Additionally, carbohydrate-based triazoles and coumarin-azole-sugar hybrid compounds also show remarkable activity. The potential of 1,2,4-triazoles in drug discovery and therapeutic applications underscores their role in medicinal chemistry.