Synthesis of New 1,2,3-Triazole Glycosides-Based Quinoline System via Click Cycloaddition

Abstract

The impact of novel compounds based small heterocyclic rings with important bioactivities promotes further research for designing and synthesizing new hybrid molecules. In the current investigation, new azido quinoline derivative has been synthesized from the commercially available 8-hydroxyquinoline. The obtained azido derivative was exploited via click chemistry to access three new 1,2,3-triazole glycosides by applying click chemistry reaction strategy. The newly synthesized compounds have been characterized by their spectral and analytical data involving ¹H, ¹³C NMR and IR. The anticancer activity of the synthesized products were evaluated agains a pannel of human cancer cell lines and the results were formulated in the form of IC₅₀ and percentage inhibition values.